Download PDF BookAllosteric Modulation of Amino Acid Receptors Therapeutic Implications (Fidia Research Symposium Series Vol 1)

[Free.MymY] Allosteric Modulation of Amino Acid Receptors Therapeutic Implications (Fidia Research Symposium Series Vol 1)

[Free.MymY] Allosteric Modulation of Amino Acid Receptors Therapeutic Implications (Fidia Research Symposium Series Vol 1)

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Book Details :
Published on: 1989-03
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Original language: English

This inaugural volume of the Fidia Research Foundation Symposium Series features contributions by leading international experts in the field of amino acid neurotransmitters--particularly the transmitters gamma-aminobutyric acid (GABA) and glutamate, two of the most common in the mammalian nervous system. The contributors present current research on the mechanisms and effects of the allosteric modulation of the receptors for these amino acids, i.e., the interactions of different ligand molecules with distinct sites within the receptor complexes resulting in the various actions of each transmitter. Topics covered include genetic cloning of one of the subtypes of the GABA receptor; the interaction of the benzodiazepines with GABA receptors; endogenous modulators for GABA receptor subtypes; a potential mechanism of transduction for GABA receptors; and the role of gangliosides and phencyclidine analogues in limiting glutamate neurotoxicity.
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